MILES D. HOUSLAY : rechercher sur Z-Library

Trends in Biochemical Sciences

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2010

Modelling the cAMP pathway using BioNessie, and the use of BVP techniques for solving ODEs

Xu Gu, David Gilbert, Des Higham, Miles Houslay

Journal:

BMC Systems Biology

Année:

2007

Langue:

english

Fichier:

PDF, 242 KB

english, 2007

Cell signalling: Dual control of adenylate cyclase

Houslay, Miles

Journal:

Anna Terrin, Giulietta Di Benedetto, Vanessa Pertegato, York-Fong Cheung, George Baillie, Martin J. Lynch, Nicola Elvassore, Anke Prinz, Friedrich W. Herberg, Miles D. Houslay and Manuela Zaccolo

Année:

1983

Fichier:

PDF, 326 KB

1983

PGE1Stimulation of HEK293 Cells Generates Multiple Contiguous Domains with Different [cAMP]: Role of Compartmentalized Phosphodiesterases

Journal:

The Journal of Cell Biology

Année:

2006

Langue:

english

Fichier:

PDF, 1.91 MB

english, 2006

Regulation of hepatocyte adenylate cyclase by amylin and CGRP: A single receptor displaying apparent negative cooperativity towards CGRP and simple saturation kinetics for amylin, a requirement for phosphodiesterase inhibition to observe elevated hepatocyte cyclic AMP levels and the phosphorylation of Gi-2

Miles D. Houslay, Nicholas J. Morris, Anne Savage, Alison Marker, Mark Bushfield

Journal:

Journal of Cellular Biochemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.70 MB

english, 1994

The selective effects of charged local anaesthetics on the glucagon- and fluoride-stimulated adenylate cyclase activity of rat-liver plasma membranes

Larry M. Gordon, Irene Dipple, Richard D. Sauerheber, Judy A. Esgate, Miles D. Houslay

Journal:

Journal of Cellular Biochemistry

Année:

1980

Langue:

english

Fichier:

PDF, 641 KB

english, 1980

The search for a molecular mechanism for the action of insulin

Miles D Houslay

Journal:

Biochemical Education

Année:

1984

Langue:

english

Fichier:

PDF, 666 KB

english, 1984

Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors

Matthew D. Cullen, York-Fong Cheung, Miles D. Houslay, Tracy L. Hartman, Karen M. Watson, Robert W. Buckheit Jr., Christophe Pannecouque, Erik De Clercq, Mark Cushman

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 136 KB

english, 2008

Noradrenergic Activity Differentially Regulates the Expression of Rolipram-Sensitive, High-Affinity Cyclic AMP Phosphodiesterase (PDE4) in Rat Brain

Ying Ye, Marco Conti, Miles D. Houslay, Shakeel M. Farooqui, Ming Chen, James M. O'Donnell

Journal:

Journal of Neurochemistry

Année:

1997

Langue:

english

Fichier:

PDF, 1.03 MB

english, 1997

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5

Graeme B Bolger, Angela McCahill, Stephen J Yarwood, Michael R Steele, Jim Warwicker, Miles D Houslay

Journal:

BMC Biochemistry

Année:

2002

Langue:

english

Fichier:

PDF, 602 KB

english, 2002

A novel role for cGMP-specific phosphodiesterase, PDE6, in active transport of cGMP

Jonathan P Day, Miles D Houslay, Shireen-A Davies

Journal:

BMC Pharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 186 KB

english, 2005

Thermotropic lipid phase separations in human platelet and rat liver plasma membranes

Larry M. Gordon, Patrick W. Mobley, Judy A. Esgate, Gary Hofmann, Anthony D. Whetton, Miles D. Houslay

Journal:

Journal of Membrane Biology

Année:

1983

Langue:

english

Fichier:

PDF, 1.14 MB

english, 1983

Upregulation of cAMP-specific PDE-4 activity following ligation of the TCR complex on thymocytes is blocked by selective inhibitors of protein kinase C and tyrosyl kinases

Alison M. Michie, Graham Rena, Margaret M. Harnett, Miles D. Houslay

Journal:

Cell Biochemistry and Biophysics

Année:

1998

Langue:

english

Fichier:

PDF, 1.37 MB

english, 1998

Discriminative stimulus effects of the type-4 phosphodiesterase inhibitor rolipram in rats

Malath M. Makhay, Miles D. Houslay, James M. O'Donnell

Journal:

Psychopharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 85 KB

english, 2001

Disrupting specific PDZ domain-mediated interactions for therapeutic benefit

Miles D Houslay

Journal:

Marchmont, Robert J., Houslay, Miles D.

Année:

2009

Langue:

english

Fichier:

PDF, 118 KB

english, 2009

Insulin triggers cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase

Journal:

Année:

1980

Fichier:

PDF, 330 KB

1980

Membrane steps

Houslay, Miles

Journal:

Wakelam, Michael J. O., Murphy, Gregory J., Hruby, Victor J., Houslay, Miles D.

Année:

1986

Fichier:

PDF, 140 KB

1986

Activation of two signal-transduction systems in hepatocytes by glucagon

Journal:

Wakelam, Michael J. O., Davies, Shireen A., Houslay, Miles D., McKay, Ian, Marshall, Christopher J., Hall, Alan

Année:

1986

Fichier:

PDF, 493 KB

1986

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

Journal:

Gawler, Debra, Milligan, Graeme, Spiegel, Allen M., Unson, Cecilia G., Houslay, Miles D.

Année:

1986

Fichier:

PDF, 493 KB

1986

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

Journal:

Houslay, Miles D, Adams, David R

Année:

1987

Fichier:

PDF, 532 KB

1987

Putting the lid on phosphodiesterase 4

Journal:

Nature Biotechnology

Année:

2010

Langue:

english

Fichier:

PDF, 367 KB

english, 2010

Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases

George S Baillie, Simon J MacKenzie, Ian McPhee, Miles D Houslay

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 177 KB

english, 2000

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

Simon J MacKenzie, George S Baillie, Ian McPhee, Carolynn MacKenzie, Rachael Seamons, Theresa McSorley, Jenni Millen, Matthew B Beard, Gino van Heeke, Miles D Houslay

Journal:

Malcolm C Shepherd, George S Baillie, David I Stirling, Miles D Houslay

Année:

2002

Langue:

english

Fichier:

PDF, 394 KB

english, 2002

Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells

Journal:

The Journal of Physiology

Année:

2004

Langue:

english

Fichier:

PDF, 440 KB

english, 2004

Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness

J. Kirsty Millar, Shaun Mackie, Steven J. Clapcote, Hannah Murdoch, Ben S. Pickard, Sheila Christie, Walter J. Muir, Douglas H. Blackwood, John C. Roder, Miles D. Houslay, David J. Porteous

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 189 KB

english, 2007

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579

Hoffmann, Ralf, Baillie, George S., MacKenzie, Simon J., Yarwood, Stephen J., Houslay, Miles D.

Journal:

The EMBO Journal

Année:

1999

Langue:

english

Fichier:

PDF, 368 KB

english, 1999

[Handbook of Experimental Pharmacology] Phosphodiesterases as Drug Targets Volume 204 || Phosphodiesterase Inhibitors in the Treatment of Inflammatory Diseases

Francis, Sharron H., Conti, Marco, Houslay, Miles D.

Année:

2011

Langue:

english

Fichier:

PDF, 201 KB

english, 2011

[Handbook of Experimental Pharmacology] Phosphodiesterases as Drug Targets Volume 204 || Therapeutic Potential of Phosphodiesterase Inhibitors in Parasitic Diseases

Francis, Sharron H., Conti, Marco, Houslay, Miles D.

Année:

2011

Langue:

english

Fichier:

PDF, 545 KB

english, 2011

Membrane phosphorylation: a crucial role in the action of insulin, EGF, and pp60src?

Miles D. Houslay, Debra J. Gawler, Graeme Milligan, Andrew Wilson

Journal:

Bioscience Reports

Année:

1981

Langue:

english

Fichier:

PDF, 933 KB

english, 1981

Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) zucker rats: Loss of functional G1 and abnormal Gs function

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 1.11 MB

english, 1989

The use of selective inhibitors and computer modelling to evaluate the role of specific high affinity cyclic AMP phosphodiesterases in the hormonal regulation of hepatocyte intracellular cyclic AMP concentrations

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 930 KB

english, 1990

Gi-2 at the centre of an active phosphorylation/dephosphorylation cycle in hepatocytes: The fine-tuning of stimulatory and inhibitory inputs into adenylate cyclase in normal and diabetic states

Journal:

Timothy M. Palmer, Peter V. Taberner, Miles D. Houslay

Année:

1991

Langue:

english

Fichier:

PDF, 712 KB

english, 1991

Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity

Journal:

Mark K. Saville, Miles D. Houslay

Année:

1992

Langue:

english

Fichier:

PDF, 943 KB

english, 1992

The role of polybasic compounds in determining the tyrosyl phosphorylation of calmodulin by the human insulin receptor

Journal:

Michael Sullivan, Mark Egerton, Yasmin Shakur, Antje Marquardsen, Miles D. Houslay

Année:

1993

Langue:

english

Fichier:

PDF, 1.37 MB

english, 1993

Molecular cloninc and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)

Journal:

Cornelia Loesberg, Sandra Spence, Frans P. Nujkamp, Miles D. Houslay

Année:

1994

Langue:

english

Fichier:

PDF, 1.77 MB

english, 1994

Dietary linoleic acid-induced changes in respiratory β-adrenergic receptor function and the form of arrhenius plots of isoprenaline- and prostaglandin E2-stimulated adenylate cyclase activity in a model for atopy

Journal:

Alison M Michie, Margaret Lobban, Thomas Müller, Margaret M Harnett, Miles D Houslay

Année:

1994

Langue:

english

Fichier:

PDF, 928 KB

english, 1994

Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: Analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 1.23 MB

english, 1996

Hard Times for Oncogenic BRAF-Expressing Melanoma Cells

George S Baillie, Miles D Houslay

Journal:

Cancer Cell

Année:

2011

Langue:

english

Fichier:

PDF, 129 KB

english, 2011

Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes

Journal:

Current Opinion in Cell Biology

Année:

2005

Langue:

english

Fichier:

PDF, 361 KB

english, 2005

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

Angela McCahill, Theresa McSorley, Elaine Huston, Elaine V. Hill, Martin J. Lynch, Irene Gall, Guy Keryer, Birgitte Lygren, Kjetil Tasken, Gino van Heeke, Miles D. Houslay

Journal:

Elaine V. Hill, Catherine L. Sheppard, York-Fong Cheung, Irene Gall, Eberhard Krause, Miles D. Houslay

Année:

2005

Langue:

english

Fichier:

PDF, 734 KB

english, 2005

Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 747 KB

english, 2006

1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, βarrestin and RACK1

K. John Smith, George S. Baillie, Eva I. Hyde, Xiang Li, Thomas M. Houslay, Angela McCahill, Allan J. Dunlop, Graeme B. Bolger, Enno Klussmann, David R. Adams, Miles D. Houslay

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2007

Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA)

Daniel M. Collins, Hannah Murdoch, Allan J. Dunlop, Erik Charych, George S. Baillie, Qi Wang, Friedrich W. Herberg, Nicholas Brandon, Anke Prinz, Miles D. Houslay

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 1.63 MB

english, 2008

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10)

Angela McCahill, Lachlan Campbell, Theresa McSorley, Arvind Sood, Martin J. Lynch, Xiang Li, Chen Yan, George S. Baillie, Miles D. Houslay

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2008

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways

Frank Christian, Diana F. Anthony, Surakiran Vadrevu, Tracy Riddell, Jonathan P. Day, Ruth McLeod, David R. Adams, George S. Baillie, Miles D. Houslay

Journal: